Abstract
Objective To investigate the clinical features, diagnosis, treatment and prognosis of gastric neuroendocrine carcinoma (G-NEC). Methods Clinical data of 52 G-NEC cases were analyzed. Follow-up was conducted by telephone. The survival curves were drawn using Kaplan-Meier method.Univariate analysis was performed by the Log-rank test and multivariate analysis was performed by COX proportional hazards model. Results The median overall survival rate was 19 months (range 6 to 61 months), and the overall 1, 3, 5-year survival rates were 74%, 16% and 5% respectively. Tumor stage surgery, vascular nerve involvement and Ⅲ and Ⅳ phase chemotherapy were related to prognosis (χ2=24.254, 10.005, 7.261, 8.790, all P<0.05). Multivariate analysis showed tumor stage and vascular nerve involvement were independent prognostic factors (χ2=17.170, 5.810, all P<0.05). Conclusion G-NEC is a highly malignant tumor with poor prognosis. Preoperative diagnosis rate is low. Surgery is the treatment of first choice. Definite diagnosis depends on postoperative pathology and immunohistochemical examination. Key words: Neuroendocrine tumors; Stomach neoplasms; Prognosis
Published Version
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