Abstract
背景与目的多原发肺癌（multiple primary lung cancer, MPLC）是一种临床中较为少见的肺癌类型，双原发肺癌（double primary lung cancer, DPLC）是其中最常见的一种，近年来由于诊疗手段的进步检出率逐渐升高。本研究总结分析了30例DPLC患者的临床资料，以期为DPLC的诊疗提供理论依据。方法回顾郑州大学附属肿瘤医院2010年1月-2015年12月收治的30例DPLC患者的临床资料，对临床特征及预后相关因素进行分析。结果30例中，同时性双原发癌（synchronous DPLC, sDPLC）占3例（3/30, 10%），异时性双原发癌（metachronous DPLC, mDPLC）占27例（27/30, 90.0%）。病灶好发于右肺上叶（20/60, 33.3%），病理类型以腺癌（25/60, 41.7%）为主，病理类型相同者（17/30, 56.7%）多于不同者（13/30, 43.3%），病理类型相同者以腺-腺（10/16, 62.5%）最常见。生存分析显示淋巴结转移（HR=4.349, 95%CI: 1.435-13.178, P=0.009）和重度吸烟史（HR=2.996, 95%CI: 1.089-8.240, P=0.034）是DPLC的不良预后因素。结论DPLC好发于右肺上叶，病理类型以腺癌为主，早期诊断、积极的治疗和严格的戒烟策略有望改善其预后。
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