Abstract

1.Intravenous antazoline caused a transient reduction in cardiac output and stroke volume. Blood pressure was maintained while peripheral vascular resistance increased.2.Antazoline exhibited both direct myocardial depressant effects and anti-acetylcholine actions.3.There was a complete suppression of atrial premature systoles in all 15 subjects studied. Atrial tachycardia was promptly terminated in 12 of 13 patients. However, antazoline proved to be ineffective in the presence of atrial flutter and fibrillation.4.All but 7 of 68 patients with frequent ventricular premature systoles had an adequate response to antazoline. Ventricular tachycardia was terminated by intravenous antazoline in 6 of 10 patients.5.Antazoline proved to be effective in terminating ventricular tachycardia, multifocal ventricular premature systoles, and nonparoxysmal nodal tachycardia due to digitalis excess. However, 1:1 conduction resulted in 2 cases of paroxysmal atrial tachycardia with block engendered by digitalis excess.6.Antazoline is an effective, well-tolerated antiarrhythmic agent which may be used in the therapy of ectopic beating of atrial, nodal, or ventricular origin.

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