Clinical and pathogenetic changes in dogs with chronic pancreatitis

Abstract

The article presents the results of chronic canine pancreatitis retrospective research based on comparison of clinical, biochemical and histopathological data. To compare the symptoms and the clinical course of chronic pancreatitis, the dogs’ with clinically confirmed diagnosis history of the disease was used. The data were obtained from the private hospital of veterinary medicine (Kyiv-city) database of pathologoanatomical records, conducted at the, regarding dogs with histological confirmation chronic pancreatitis that was determined based on pancreatic tissue irreversible histological changes (fibrosis and atrophy). It was established that most often chronic pancreatitis manifests by apathy, appetite decreasing, vomiting and diarrhea. Chronic pancreatitis is more common in old decorative breed dogs that have been sterilized, with the simultaneous pathology of the endocrine, hepatobiliary and nervous systems. In sick dogs’ blood serum observed high levels of enzymes that reflect the functional state of the liver and pancreas, increased bilirubin levels. At histological researches observed necrosis of pancreatic and surrounding connective tissues. The results of our research indicate that dogs’ chronic pancreatitis has no clear clinical signs, however, the most common symptoms are diarrhea, abdominal pain, chronic vomiting, loss of appetite. The most common clinical and biochemical disorders were increased serum transaminases and bilirubin concentrations. The similarity of clinical signs in dogs with acute and chronic pancreatitis shows us that chronic pancreatitis may be the result of acute pancreatitis numerous attacks. For our opinion, the pathogenesis of dogs’ chronic pancreatitis based on necrotic pancreas process and the replacement of normal tissues on fibroids. Probably, that in an animal with chronic pancreatitis, without the presence of pancreatic and surrounding tissue necrosis, specific clinical signs develop less frequently. In our research, we differentiated them as patients with chronic pancreatitis based on a histopathological research.