Clinical and Metabolic Studies on Werner’s Syndrome: With Special Reference to Disorders of Lipid and Liver Function

Abstract

In a clinical study of patients with Werner's syndrome, it became apparent that careful observation of numbers of patients could result in the addition of new or modified signs and symptoms to those already known. In addition of flat feet and hyperreflexibility, it was observed that the irregular disarrangement of the teeth and thin, sparse and colour-faded hair were frequently occurrences in patients with Werner's syndrome. In the laboratory survey, disorders of lipid metabolism and liver function were detected in 3 out of 24 cases of Werner's syndrome. It was concluded that the disturbances of lipid metabolism result in part from moderate liver dysfunction.