Clinical and laboratory substantiation of the effectiveness of professional oral hygiene in preparation for orthopedic treatment with the use of fixed structures of dentures.

Abstract

Вackground: To extend the service life of fixed orthopedic structures of dentures, it is necessary to conduct professional oral hygiene (PGPR) before orthopedic treatment based on changes in the cytokine profile in the gingival fluid (J).
 Аims:The aim of the study was to assess the nature of changes in the cytokine profile in the gingival fluid during orthopedic treatment with the use of fixed denture structures before and after the PGPR
 Material and methods of research: The examined patients were divided into 3 groups: group 1 patients with intact periodontitis 10 people; group 2 patients with mild periodontitis 10 people; group 3 patients with moderate periodontitis - 10 people. The examination was carried out before the installation of fixed orthopedic structures, before, and a week after PGPR. Six mediators of immunoregulatory processes, interleukin-6 (IL6), interleukin 1-beta (IL1), tumor necrosis factor alpha (TNF-a); chemokines (IL8, MCP1); vascular endothelial growth factor VEGF, were quantified in J samples by solid-phase enzyme immunoassay
 .Results: In patients with inflammatory periodontal diseases, a high content of IL1, IL6, IL8, MCP1, as well as VEGF was found in J compared with the group of examined individuals without inflammatory periodontal diseases. After PGPR, in patients with inflammatory periodontal diseases, there was a drop in the content of the main pro-inflammatory cytokines/chemokines in the blood and the level of VEGF.
 Conclusions: A decrease in the content of proinflammatory cytokines, chemokines and VEGF in J after the PGPR procedure leads to the blockade of inflammatory and destructive processes in periodontal tissues and allows the introduction of personalized practice of preparing supporting teeth in the oral cavity for permanent prosthetics