Clinical and Laboratory Features of Infectious Mononucleosis in Children Depending on the Etiology of the Disease

Abstract

Study of clinical and laboratory features of infectious mononucleosis (IM) in children depending on the etiological variant of the disease. The study involved 94 children aged 4 months to 15 years old with a diagnosis of «infectious mononucleosis». The study analyzed the etiologic structure of IM, clinical and laboratory features of its individual etiological variants. The findings showed that the most common cause of myocardial infarction in children under the age of 15 years is HHV-6, which is more common as monoinfection (51.06% of the total number of patients with IM), at least — in association with EBV and CMV. IM mixed etiology recorded in 29.79% of cases. The acute phase of infectious mononucleosis, regardless of the etiology of the disease is accompanied by a moderate leukocytosis, accelerated erythrocyte sedimentation rate, an increase in alkaline phosphatase activity. The level of IL-4 in the blood varies depending on the etiology of the disease and is the highest at the infarction caused by EBV. Severity of the clinical picture varies depending on the etiology of the disease. The most pronounced intoxication, lymphoproliferative and hepatolienalis syndromes were identified in children with IM-EBV, IM-HHV-6 and IM mixed etiology (version «EBV + HHV-6»). Determination of etiologic variant of IM is relevant for the diagnosis of disease, prediction of its course and possible complications.