Abstract
Thyroid hormones regulate lipid and lipoprotein metabolism; Therefore, thyroid dysfunction induces significant changes in lipid levels. This study was carried out to study the prevalence of thyroid disease and observe the association between hypothyroidism and serum cholesterol levels. A cross-sectional study enrolling all 50 diagnosed hypothyroid patients coming to the hospital lab irrespective of age and sex was selected, conducted during 2018-2020. The present study was conducted in the department of biochemistry in fifty hypothyroid male and female cases and 50 healthy controls. Serum triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), Total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and Triglycerides were estimated in these patients, and the results were analyzed. Mean values of Serum Cholesterol in cases (<0.001), there was a significant difference between serum cholesterol of hypothyroid cases and controls with p-value <0.001. There was a significant difference between serum TSH of hypothyroid cases and controls with a p-value <0.000. We found that in other investigations FBS, TG, VLDL, T3 & T4, the p-value was found significant among cases and controls. In the present study, we concluded that TSH level is increased and T3 and T4 levels are decreased in hypothyroid patients, creatinine, and cholesterol levels are increased in hypothyroid patients. We observed that there is an increase in TSH levels as age increases. We can say that any change in thyroid hormone levels alters skeletal muscles' functioning and decreases renal perfusion and filtration capacity.
Published Version
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