Abstract
Aim of the research – to assess the clinical and laboratory parameters in patients with chronic hepatitis C (CHC) on the early stages of development and their comparison with the level of galectin3. The study included 78 patients with oligosymptomatic course of the disease and minimal liver fibrosis in the most cases. In the most patients with stages of the disease exceeding 8 years, viral load was over a million copies/ml. In 10 % of patients on the early stages of the disease, changes corresponding to severe liver fibrosis and cirrhosis F3 and F4 were detected. Moderate correlation of ALT activity, viral load and low severity with the duration of the disease was identified. There is a trend towards a higher level of galectin3 in a long course of CHC in comparison with earlier stages of its development, with significantly higher average level of galectin-3 in patients with minimal liver fibrosis (F0–F1) as compared to advanced stages, suggesting its importance in the launching and initial mechanisms of fibrogenesis.
Highlights
Reduction of minimal residual disease to undetectable levels is the key criterion for efficiency of allogeneic hemato poietic stem cell transplantation, along with engraftment of transplanted cells with complete replacement of recipient hematopoiesis, i. e., full post transplant chimerism
Содержание галектина 3 в сыворотке крови оп ределяли методом твердофазного иммунофермен тного анализа (ELISA) с использованием набора ре активов «DRG Insulin ELISA (EIA – 2935)» (DRG Diag nostics, США)
В связи с вышеизложенным, представляется ак туальным изучить профиль молекулярно генети ческих нарушений при ОГМ у детей с целью опре деления потенциальных кандидатов для лекар ственной терапии с направленным механизмом действия
Summary
Reduction of minimal residual disease to undetectable levels is the key criterion for efficiency of allogeneic hemato poietic stem cell transplantation (alloHSCT), along with engraftment of transplanted cells with complete replacement of recipient hematopoiesis, i. e., full post transplant chimerism. Molecular genetic techniques are preferable, being based on the analysis of highly poly morphic DNA sequences (short tandem repeats, STRs). This approach, despite its high specificity, has a limited sensitivity. В то же время не исключается возможность длительного торпидного течения гепатита с мини мальными темпами прогрессирования фиброза печени. Одной из важных проблем клинической прак тики является определение индивидуального прогноза течения ХГС, который во многом зави сит от объективной оценки выраженности и темпов развития фиброза печени. Целью исследования явилась оценка клинико лабораторных показателей у больных ХГС на ран них сроках развития и их сопоставление с уровнем галектина 3
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