Clinical and immunological features of infants born from mothers with threatened miscarriage

Abstract

Most of researchers denote predominance of morbid conditions, originated from prenatal period of life, in infant disease structure. To their mind, these points to the interrelation between these diseases and mother’s somatic health and het gestation course. The goal of the research was to study how the feto-maternal disease influences clinical and immunological status of infants at neonatal age. The observance has been held under 73 infants, born from mothers with different types of gestation. The first group contained infants, born from mothers with physiologic gestation course, the second group - infants, born from mothers with threatened miscarriage. The clinical laboratory examination of newborns and infants included evaluation of anthropometric characteristics, somatic status, ultrasound examination of thymus, indexes of cellular immunity. The examiners used diagnostic immunoenzymometric test-systems of JSC «Vektor-Best» and standardized methods. The newborns of the second group had the most apparent aberrations of physical growth and development. The central nervous system depression in the form of encephalitic depression syndrome has been detected as the common consequence of severe prenatal fetal hypoxia and neonatal asphyxia of second group newborns. Moreover, infants, born from mothers with threatened miscarriage, predominantly had «abnormal small thymus’s syndrome». The results of immunological examinations showed that infants’ cellular-immunity changes depended on nature of mother’s gestation disorders (suppressor type dependence). The developing of evident immune suppression with signs of immunological tolerance disorder has been detected amongst infants, born from mothers with threatened miscarriage. The initial symptoms were allergenic dermhelminthiasis.