Clinical and experimental observations with methiodal, an absorbable myelographic contrast agent.

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The intrathecal iniectuni of methiodal in myelography is associated with spinal anesthesia, pain, and autonomic dysfunction. Experiments carried out in cats revealed that methiodal blocked conduction in the ventral and dorsal route fibers, an action which did not develop in peripheral nerves. Other experiments in cats indicated that the duration of the effects on conduction is a consequence of slow removal of the drug rather than of delayed recovery. The results of these experiments are taken to indicate that the effects of methiodal may be ascribed to an action on the spinal cord or nerve roots.