CLINICAL AND EPIDEMIOLOGICAL ASPECTS OF EPILEPSY IN CHILDREN AND ADOLESCENTS LIVING IN KRASNOYARSK REGION

Abstract

The high prevalence of epilepsy in the pediatric population, significant cognitive, psychological and social consequences of this disease determine the problem urgency and the need for research. Previously there were no clinical-epidemiological study of epilepsy in the pediatric population in the Krasnoyarsk region (KR). This study estimates prevalence of epilepsy among children and adolescents in the KR, specifies gender and age variations of the disease onset, analyzes epileptic syndromes structure. The study included 1032 patients aged 0 to 17 years with epilepsy. General and primary morbidity in KR within the last 3 years was at the same level: in 2012 – 5,9 and 1,4, respectively, in 2013 – 5,65 and 1,3, in 2014 – 5,96 and 1,5 per 1000 children; in 2012 – 7,3 and 1,4, respectively, in 2013 – 7,3 and 1,5, in 2014 – 7,9 and 1,3 per 1000 adolescents. These parameters are greater than those in the Siberian Federal District and the Russian Federation; boys are more likely to suffer from epilepsy (54%) than girls (46%). The epilepsy onset occurs mainly at age from 0 to 1 year (26%) and 4–6 years (24%), significantly more rare manifestation occurs in adolescence (4%). In the structure of epilepsy syndromes prevail symptomatic focal (41%) and cryptogenic focal epilepsy (28%); third and fourth place take idiopathic focal epilepsy (18%) and idiopathic generalized epilepsy (10%) respectively; less numerous group is epileptic encephalopathy (3%). Study results allow to discuss the strategy of dispensary observation of patients with epilepsy, to plan surveys financing and drug supply and organization of medical and social care for patients with epilepsy and their families.