Abstract
The aim of our work was to study the COMP level in the blood serum of patients with type 1 and type 2 diabetes with arthropathy and to determine the relationship with functional indices characterizing the clinical manifestations of joint damage in patients with diabetes mellitus.Materials and methods. The study involved 87 patients (35 men and 52 women) with diabetes. Patients were divided into groups depending on the type of diabetes and the presence of arthropathy. Patients were examined using a visual analogue scale, Lequesne’s index and WOMAC scale. Cartilage oligomeric matrix protein (COMP) was determined by enzyme immunoassay.Results. The presence of diabetic arthropathy was found in 78 % of patients with type 1 diabetes and in 80 % of patients with type 2 diabetes. In the vast majority of patients (20 with type 1 diabetes and 30 with type 2 diabetes), the joints of the upper extremities were involved in the pathological process. We found an increase in functional indices in patients with arthropathy in both types of disease: Lequesne’s index – t = -5.5, P = 0.001 – in patients with type 1 diabetes, t = -6.9, P = 0.001 – in patients with type 2 diabetes, WOMAK index (t = -5.4, P = 0.001), (t = -7.8, P = 0.001); visual analogue scale (t = -6, P = 0.001), (t = -6.9, P = 0.001), respectively. Average COMR values significantly increased with the arthropathy stage progression (t = -3.4, P = 0.005; t = -2.4, P = 0.0023; t = -3.2, P = 0.006) in patients with type 1 diabetes. In patients with type 2 diabetes, the significance of differences was found between the control group and patients with stage 1 (t = 3.4, P = 0.001), between stages 1 and 2 (t = -4.1, P = 0.001). A direct correlation was established between the presence of arthropathy and the COMP level (r = 0.76, P = 0.001), between the presence of arthropathy and the Lequesne’s index (r = 0.76, P = 0.001), the visual analogue scale (r = 0.88, P = 0.001) and WOMAC (R = 0.88, P = 0.001).Conclusions. The results suggest that arthropathy in patients with type 1 and type 2 diabetes is characterized by an increase in the cartilage degradation marker directly related to the severity and the number of joints affected.
Highlights
Мета роботи – дослідити рівень Cartilage oligomeric matrix protein (COMP) у сироватці крові хворих на цукровий діабет (ЦД) 1 і 2 типу з артропатіями та визначити взаємозв’язок із функціональними індексами, що характеризують клінічні прояви ураження суглобів у хворих на цукровий діабет
The presence of diabetic arthropathy was found in 78 % of patients with type 1 diabetes and in 80 % of patients with type 2 diabetes
In the vast majority of patients (20 with type 1 diabetes and 30 with type 2 diabetes), the joints of the upper extremities were involved in the pathological process
Summary
ДУ «Інститут ендокринології та обміну речовин імені В. Середні показники COMP вірогідно збільшувалися з прогресуванням стадії артропатії (t = -3,4, p = 0,005; t = -2,4, p = 0,0023; t = -3,2, p = 0,006) у хворих на ЦД 1 типу. У хворих на цукровий діабет 2 типу вірогідні зміни визначили між відсутністю артропатії та її 1 стадією (t = -3,4, p = 0,001), а також між 1 та 2 стадіями (t = -4,1, p = 0,001). Сильної сили прямий кореляційний зв’язок визначили між наявністю артропатії та індексом Лекена (r = 0,76, p = 0,001), шкалою ВАШ (r = 0,88, p = 0,001) та WOMAK (r = 0,88, p = 0,001). Результати дають підстави стверджувати, що артропатія у хворих на цукровий діабет 1 та 2 типу характеризується підвищенням маркера деградації хряща в прямій залежності від тяжкості та кількості уражених суглобів. The aim of our work was to study the COMP level in the blood serum of patients with type 1 and type 2 diabetes with arthropathy and to determine the relationship with functional indices characterizing the clinical manifestations of joint damage in patients with diabetes mellitus
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