Clinical analysis on 20 cases of invasive pulmonary aspergillosis

Abstract

Objective To investigate high-risk factors, clinical features, imaging features, treatment and prognosis factors in the incidence of invasive pulmonary aspergillosis. Methods A retrospective analysis was carried out to 20 cases of clinical data in our hospital diagnosed as pulmonary aspergillosis infection from January 2008 to June 2012.Resuhs In the 20 cases of invasive pulmonary aspergillosis, there were 15 patients found with immunodeficiency, 5 cases of previously healthy. Clinical features： fever 14 cases （70%）, cough in 12 patients （60%）, sputum in 10 patients （50%）, shortness of breath, 8 cases （40%）, pleural effusion in 4 cases （20%）, 4 cases of chest pain （20%）, hemoptysis in 12 cases （60%）. Imaging features： 5 cases of nodules, lumps shadow 3 cases, 2 cases of ground-glass infiltrates, 4 cases of empty and crescent sign 3 cases, large tracts of real change 3 cases. 18 patients with the antifungal drug voriconazole, 2 cases of surgical treatment. Prognosis： cured 10 cases, 5 cases effective, 2 cases giving up, and 3 patients died. Conclusion The clinical features and imaging features of invasive pulmonary aspergillosis are not specific, the diagnosis relies on etiology and pathological examination. Early diagnosis to patients with immunodeficiency by using voriconazole therapy can improve the cure rate, and provide a good prognosis for patients without high risk factors. Key words: Pulmonary aspergillosis; Voriconazole