Clinical analysis of 22 cases of invasive pulmonary aspergillosis

Abstract

Objective To analyze the clinical features of invasive pulmonary aspergillosis ( IPA),and deepen our understanding of the disease.Methods Clinical datas of 22 cases of IPA in our hospital from June 2000 to June 2010 were retrospectively analyzed. Results Twenty - one patients (95.5％) suffered from underlying diseases in 22 IPA cases.The incidence of symptoms was 90.9％ for productive cough,59.1％ for fever,50.0％ for breathlessness or dyspnea,45.5％ for haemoptysis,31.8％ for chest pain.By chest radiography,bilateral multiple pulmonary similar round mass or nodules was found in 54.5 ％,bilateral pulmonary infiltrates with mutiple cavitations in 31.8 ％,bronchopneumonia in 9.1％,consolidation like wedge in 4.5％.Among the 22 subjects,8 cases(36.4％ ) were proven and 14 cases(63.6％ ) were probable IPA.The effective rate of 20 patients receiving anti -fugus therapy was 65.0％.Conclusions A majority of ivasive pulmonary aspergillosis developed from underlying diseases,bilateral multifocal nodules and cavitions could be most common radiological characterisic,early diagnosis and treatment are critical for reducing the mortality of IPA. Key words: Pulmonary aspergillosis; Chest radiography; Diagnosis; Therapy