Clinical analysis of risk factors for pulmonary embolism and joint detection of cTnT, BNP, CRP, D-dimer

Abstract

Objective To review the risk factors of pulmonary embolism and explore the combined detection of cardiac troponin T( cTnT), brain natriuretic peptide (BNP), C-reactive protein (CRP), D-dimer for diagnosis and risk stratification of the guiding significance. Methods All 103 patients with acute pulmonary embolism were collected by clinical manifestation and auxiliary examination confirmed from August 2014 to July 2016 in department of respiratory of Tangdu Hospital of Fourth Military Medical Unirersity and divided into high-risk group, the moderate-risk group, the low risk group, retrospectively analyzed the risk factors and abnormal index. Results The incidence of deep venous thrombosis was the most important risk factor in 46.6%, followed by age>65 years old 39.8%, cardiovascular disease 26.2%, tumor 22.3%, surgery 18.4%, chronic lung disease 17.5%, trauma and fracture 13.6%. Again, lower limb varicose veins or phlebitis 9.7%. The abnormal checking indicators: The patients of D-dimer increased accounted for 96.117% in three groups. There were no statistical difference between them(P=0.217). The number of elevated cTnT, BNP and CRP in high-risk group and moderate-risk group were higher than that in low-risk group, the high-risk group was also higher than moderate group, each group compared to statistically significant(P<0.05). Conclusions Deep vein thrombosis was the most important risk factors of pulmonary embolism. The sensitive of elevated D-dimer was the most in pulmonary embolism. There was D-dimer-negative pulmonary embolism and cTnT, BNP and CRP were positively correlated with risk stratification. Key words: Pulmonary embolism; Risk factors; Risk stratification; Cardiac troponin T; Brain natriuretic peptide; C-reactive protein; D-dimer