Correlation analysis of BNP, TNI level change and pulmonary embolism

Abstract

Objective To investigate the relationship between plasma brain natriuretic peptide (BNP) and troponin I (TNI) and the severity and prognosis of pulmonary embolism. Methods 88 patients with acute pulmonary embolism treated in Shangqiu First People′s Hospital from February 2015 to December 2016 were selected, including 16 cases of high-risk, 35 cases of intermediate-risk, and 37 cases of low-risk.The levels of BNP and TNI of patients were detected. Results The levels of BNP and TNI in high-risk group were (384.22±39.41) ng/L and (2.40±0.83) μg/L, which were significantly higher than those in intermediate-risk group and low-risk group (all P<0.05). The levels of BNP and TNI in intermediate-risk group were (254.12±52.16) ng/L and (1.35±0.29) μg/L, which were significantly higher than those in low-risk group (all P<0.05). BNP and TNI were positively correlated with the patients′ condition (rs=0.322, 0.301, all P<0.05). There was no correlation between BNP and TNI.BNP and TNI of death patients in high-risk group were (405.63±33.42) ng/L and (2.65±0.94) μg/L, which were significantly higher than those of survival patients (F=42.106, 10.813, all P<0.05). Conclusions The levels of BNP and TNI in patients with pulmonary embolism are positively correlated with patients′ condition, have some relationship with the prognosis of patients, and have important guiding significance in clinical diagnosis and prognosis judgment. Key words: Brain natriuretic peptide; Troponin I; Pulmonary embolism; Condition; Prognosis