Abstract
Objective To analyze the value of preoperative neutrophil / lymphocyte ratio and platelet/lymphocyte ratio in predicting lymph nodes metastasis of patients with gastric cancer. Methods Clinical data of 103 patients with gastric cancer treated in our hospital from January 2016 to June 2018 were analyzed retrospectively. According to the pathological results, they were divided into lymph node metastasis group (39 cases) and no lymph node metastasis group (64 cases). Spss20.0 softwarewas used for data analysis.Measurement data such as preoperative inflammation index, NLRand PLR were presented as mean+ standard deviation and were examined by using t test. TNM staging and other count data were compared with χ2 test. To draw the ROC curve and calculate the critical value of NLR, PLR. P<0.05 was considered assignificant difference. Results There was no significant difference of white blood cell count betweentwo groups before operation (P=0.156). However, the neutrophils, platelets and lymphocytes in preoperative lymph node metastasis group were higher than those without lymph node metastasis group respectively with significant difference (P=0.037, 0.044, 0.047). The NLR and PLR ofpatients withlymph node metastasis was significantly higher than those of patients without lymph node metastasis, with significant difference (P=0.000). In terms of NLR, the area under the curvewas 0.814, the 95%CI was (0.688±0.851), the critical value was 2.01, the sensitivity was 88.4%, and the specificity was 43.1%. In terms of PLR The area under the curve of PLR was 0.809, 95% CI was (0.704~0.864), the critical value was 148.63, the sensitivity was 80.6%, and the specificity was 46.7%. Conclusion Preoperative NLR and PLR have potential value in predicting lymph node metastasis of patients with gastric cancer. Key words: Stomach neoplasms; Lymphatic metastasis; Blood platelets; Lymphocytes; Forecasting
Published Version
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