Clinical analysis of glucose level and blood lipid level in predicting the risk of gestational diabetes mellitus

Abstract

Objective To evaluate the value of fasting plasma lipid levels and fasting plasma glucose (FPG) levels in predicting gestational diabetes mellitus (GDM) in pregnant women between 8 and 16 weeks. Methods A total of 878 pregnant women with routine prenatal examination were selected. According to the glucose tolerance of pregnant women, they were divided into GDM group (n=99) and normal glucose tolerance group (n=779). General data of pregnant women were collected, and the blood lipid index and FPG index were examined at 8-16 weeks of gestation. The independent risk factors of GDM were evaluated by Logistic regression analysis, and the prediction model of GDM risk was established. The Hosmer-Lemeshow goodness-of-fit test was used to evaluate the fitting capacity of GDM model. Results FPG levels were positively correlated with blood glucose of OGTT at fasting (r=0.447), after taking glucose for 1 h (r=0.178) and after taking glucose for 2 h (r=0.143), respectively (P 3 times (OR=1.779, 95%CI: 1.082-2.931) were independent risk factors of GDM in pregnant women (P 3. The Hosmer-Lemeshow goodness-of-fit test showed P=0.955, which predicted the ROC curve under risk of GDM occurrence had a surface area AUC of 0.762 (95%CI = 0.729-0.793, P=0.028), a cut-off value of 0.12, a sensitivity of 68.6% and a 1-specificity of 71.6%. Conclusions Gestational diabetes mellitus in pregnanc women (GDM) can be predicted by establishing a predictive model combining laboratory indexes and clinical indexes of pregnant women with 8-16 weeks gestational diabetes. Key words: Gestational diabetes mellitus; Blood glucose; Blood lipid; Prediction model