Abstract
Objective To investigate possible pathogenesis characteristics of pulmonary infection in patients with chronic kidney disease (CKD2-4) and to find risk factors for poor prognosis. Methods A total of 177 patients with chronic renal disease who were hospitalized from May 2015 to February 2017 in our hospital were selected.All patients were divided into two groups, 88 patients without pulmonary infection (non-infection group) and 89 patients with chronic kidney disease with pulmonary infection (pulmonary infection group). Pathogen, age, sex, basic diseases and other clinical data of 89 patients with pneumonia were analyzed.Multi-factor unconditioned logistic analysis were apply to define the affecting prognosis risk factors for pneumonia. Results Of 177 patients with chronic renal disease were included in this study and 89(50.2%)patients with pneumonia were diagnosed.The mean age was (58.54±15.95) years. There was no statistically significant difference between age, gender, history of smoking, and basic disease.Statistical significance was found in patients who take hormones and immunosuppressants were more likely to get pneumonia.The sputum specimen that were obtained from 89 patients with pulmonary infection were cultured, and 39 patients were cultured positive, with the positive rate 43.8%.Totally 39 strains of pathogens were isolated, include 31(79.4%)strains of gram-negative bacteria. The escherichia coli and klebsiella pneumoniae were 22.5% of gram-negative bacteria, and the pseudomonas aeruginosa and the narrow-eating monocytosis were 16.1% of gram-negative bacteria. Seventy-five cases of pulmonary infection were cured, the cure rate was 84.2% and 14 cases died, accounting for 11.87%.The risk factors of death for patients with chronic nephropathy combined with pulmonary infection showed that there was statistical significant in diabetes, hormone and immunosuppressive agents, absolute decreased lymphocytes, and increased distribution of red blood cells by multi-factor unconditioned logistic analysis. Conclusions Such as patients with diabetic or received glucocorticoid and immunosuppressive drugs, decreased lymphocyte absolute value, and increased RBC distribution width are associated with poor prognosis for pulmonary infection in chronic renal disease. Key words: Kidney Diseases; Pneumonia
Published Version
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