Abstract
This paper aims to make an epidemiological investigation of a group toxication of acute clonidine, identify the clinical characteristics and propose the treatment measures, and study the safety and effect of Hemoperfusion (HP) through clinical analysis of the cases. All the epidemiological data were collected from 80 cases in “4.23” clonidine poisoning event in Huairou District of Beijing. The clinical records of all the 34 severe acute clonidine poisoning cases after treatment of HP with HA230 hemoperfusion cartridge were collected, after comprehensive analysis of the symptoms, physical signs, laboratory index, HP treatment and clinical responses, then a reliable conclusion was obtained. HP treatment could effectively reduce the level of serum clonidine by (81±12)% of acute clonidine poisoning treated after the first HP. After 1-3 times of HP treatment, the clonidine level of serum and urine could be reduced to nearly the normal level. The patients in all cases totally recovered without lingering effects and side effects. Group cases of acute clonidine poisoning often have high-level concealment, severe symptoms, high risks, and difficulty of treatment. It is suggested that HP is an effective method to reduce the clonidine level in blood and urine.
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