Abstract
SUMMARYHuman peripheral lymphocytes cultured in vitro for 72 h have been used to compare the cytotoxic and clastogenic activity of water soluble compounds containing hexavalent chromium (as sodium dichromate, Na2Cr2O7) or trivalent chromium (as chromium chloride, CrC13).In the cultures treated for the last 24 h with different concentrations of Na2Cr2O7 (from 0.1 up to 50 × 10−6M), a decrease of the mitotic index and an increase of the percentage of cells with chromosome aberrations are noticed, which are linearly correlated with the logarithm of increasing Cr (VI) concentrations. Chromatid type aberrations are always prevalent and their frequency increases with a strongly inclined regression slope, whereas chromosomal type aberrations increase more slowly with the increasing Cr (VI) concentrations.In the cultures treated for the last 24 h with different CrCl3 concentrations (from 10 up to 7500×l0−6M), no significant increase of chromosome aberrations is noticed, not even when the cells are exposed to subt...
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