Citrullus colocynthis and Silbum Marian as therapeutic agent in metabolic syndrome Rrattus model

Abstract

Background: Plants represent a treasure chest with many unrevealed medical applications as hypoglycemic and antioxidant roles. A pathological condition characterized by hyperglycemia, insulin resistance, and dyslipidemia known as metabolic syndrome. Objectives: This work focuses on examining the hypoglycemic effect of three plants on a metabolic syndrome( MS)-induced animal model and studying the role of the extracted phenolic compounds on different mitochondrial function genomic parameters. Methods: Citrullus colocynthis, Silbum Marian, and Rheum rhabarbarum phenolic compounds extracted and quantified using the Folin–Ciocalteu reagent, as described by Sánchez-Rangel et al. (2013).Forty albino rats were included in the work. They were divided into eight groups of five animals each as follows: negative control (normal), positive control (MS induced with fructose with no treatment), and MS treatment with Citrullus colocynthis, MS treatment with Silbum Marian, and MS treatment with Rheum rhabarbarum. Non-MS animals treated with Citrullus colocynthis Non-metabolic syndrome animals treated with Silbum Marian and non-MS animals treated with Rheum rhabarbarum. Serum glucose, Lipid profile, liver function tests, serum glucose, lactate, pyruvate, and molar lactate/pyruvate ratio. Genomic study was conducted by qPCR Conclusion: metabolic syndrome significantly reduce mitochondrial genome copies number. The application of the ethanolic extract of Citrullus colocynthis and Silbum Marian