Cistus × Incanus L. Pandalis and Its Broad Antiviral Properties

Abstract

Derived from Cistus x incanus L. Pandalis, the extract Cystus Pandalis^® has been subject to several examinations concerning its antiviral effect. Its effectiveness has been proven in all examinations in-vitro and in-vivo. In physiological dosages, the Infection of cell cultures by applied viruses was completely prevented in-vitro without the cells being affected by Cystus Pandalis^® extract. Likewise, the application of Cystus Pandalis^® extract in-vivo showed that it prevented the infection of subjects, in contrast to subjects of the control group living in similar life situations. The effect is based presumebly on the specific highly concentrated polyphenols typical to the variety in the used extract. Its dense concentration of polymeric polyphenols (over 90%) in contrast to its relativeley low content of monomeric polyphenols (about 2%) seems to be key to this specific extract. So it blocks the cellular attachment sites and inhibits the virus from entering. As it is for SARS-CoV-2, it seems plausible that the extract encases surface proteins (in this case the Spike-Protein) to prevent the virus from attaching to the human cell and, therefore, avert infection. Cystus Pandalis^® extract is available as lozenges or mouthrinse in form of a decoction. Prophylactic use during infectious waves and viral epidemics/pandemics at any stage is easily feasible. The extract is well-tolerated and has caused no known sideeffects. So far, no viral resistances or the development thereof have been detected. In Addition, no contraindications or interactions with other drugs are known to date. Cystus Pandalis^® extract is freely available and can be applied regardless of age or sex.