Abstract
We investigated the possible use of a local chemotherapy in the treatment of malignant lesions in bone. Therefore, the diffusion of cisplatin from polymethyl methacrylate implants was studied in vitro and in vivo in rabbits. Cisplatin-loaded implants were prepared by extemporaneous polymerization of methyl methacrylate added to a poly (methyl methacrylate)/drug blending. The in vitro release rate of cisplatin was very slow and incomplete, but increased when the drug loading was higher, suggesting a percolation release model. In vivo, drug-loaded implants showed sustained release characteristics and no plasma peak, compared to control intravenous cisplatin administration. After implantation, local concentrations of platinum were higher in bone marrow than in bone tissue. Comparative safety studies with cisplatin infusion showed a slight, but not clinically significant, renal and haematologic toxicity for drug-loaded implants.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
