Circulating Vitamin D Level in Asymptomatic Helicobacter Pylori Infection Patients

Abstract

Background: Helicobacter pylori (H. pylori) infection is one of the most risk factors for gastric cancer. More than 80 % of H. pylori infection was demonstrated as asymptomatic infection. Vitamin D was recently found to play important roles in many diseases including infectious disease and cancer. While the level of vitamin D in asymptomatic H. pylori infection was rarely reported, so we investigated serum vitamin D concentration in asymptomatic H. pylori infection in this study.Methods: Data for 3567 people were collected and analyzed, 182 of whom were identified as asymptomatic H. pylori infection without any other disease. H. pylori infectionstatus was determined by carbon-13 urea breath test. Serum 25-hydroxyvitamin D, was detected with ELISA. Periphery leukocyte, neutrophile and lymphocyte frequencies were detected with standard automated clinical methodologies.Results: No significant different serum 25-hydroxyvitamin D concentration was found between asymptomatic H .pylori infection patients and normal healthy control. Asymptomatic H. pylori infection patients had significantly higher periphery leukocyte and neutrophile frequencies than those in normal healthy control.Conclusion: Asymptomatic H. pylori infection status did not influence the concentration of circulating vitamin D.