Abstract
BackgroundActivation of receptor for advanced glycation end products (RAGE) leads to the proinflammatory response and the release of its soluble form (sRAGE) which appears to function as an anti-inflammatory feedback mechanism.AimTo determine serum sRAGE concentration in CSU patients and its association with C-reactive protein (CRP) concentration, a nonspecific inflammatory marker of the disease activity.MethodsConcentrations of sRAGE and CRP were measured in serum of CSU patients and compared with the healthy controls.ResultsSerum sRAGE concentrations were significantly decreased in CSU patients, especially those more severely affected. In addition, significant inverse correlations were observed between sRAGE and CRP concentrations.ConclusionsDown-regulation of sRAGE and its association with acute phase response suggest a role for RAGE activation in the pathogenesis of CSU. It seems that lower serum sRAGE concentration may enhance the urticarial processes.
Highlights
The pathogenesis of chronic spontaneous urticaria (CSU) is complex and involves a number of mediators [1,2,3,4].The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules, playing an important role in immune/ inflammatory disorders [5,6,7,8,9]
Serum soluble form of RAGE (sRAGE) concentrations were significantly decreased in CSU patients, especially those more severely affected
3 Department of Gynaecology, Obstetrics and Oncological Gynaecology, SMDZ in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland activation in the pathogenesis of CSU. It seems that lower serum sRAGE concentration may enhance the urticarial processes
Summary
The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules, playing an important role in immune/ inflammatory disorders [5,6,7,8,9]. This multiligand receptor binds a variety of molecules, including advanced glycation end products (AGEs), amyloid fibrils, S100/calgranulins and amphoterin, which lead to the inflammatory response and cellular dysfunction. Activation of receptor for advanced glycation end products (RAGE) leads to the proinflammatory response and the release of its soluble form (sRAGE) which appears to function as an anti-inflammatory feedback mechanism. Aim To determine serum sRAGE concentration in CSU patients and its association with C-reactive protein (CRP) concentration, a nonspecific inflammatory marker of the disease activity
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