Circulating soluble neuropilin-1 in patients with early cervical cancer and cervical intraepithelial neoplasia can be used as a valuable diagnostic biomarker.

Shouhua Yang,Henghui Cheng,Xiaoling Wang,Zaiju Huang,Zehua Wang,Yinglu Wan,Jing Cai

doi:10.1155/2015/506428

Shouhua Yang, Henghui Cheng + Show 5 more

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https://doi.org/10.1155/2015/506428

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Abstract

Objective. To investigate soluble neuropilin-1 (sNRP-1) in circulating and NRP-1 protein in cervical tissues from patients with cervical cancer or cervical intraepithelial neoplasia (CIN). Methods. sNRP-1 was measured in 64 preoperative patients and 20 controls. NRP-1 protein in cervical tissue was detected in 56 patients and 20 controls. Results. Both sNRP-1 and NRP-1 proteins were correlated with stage. sNRP-1 presented a high diagnostic ability of cervical cancer and CIN, with a sensitivity of 70.97% and a specificity of 73.68%. Conclusions. sNRP-1 in circulating can serve as a possible valuable diagnostic biomarker for cervical cancer and CIN.

Highlights

Cervical cancer is the fourth most common cancer in women worldwide, and it has the fourth highest mortality rate among cancers in women [1]
We found that circulating soluble neuropilin-1 (sNRP-1) levels in patients with cervical cancer and cervical intraepithelial neoplasia (CIN) were significantly higher than those of the controls (P < 0.01, resp., Figure 1(a))
There was no significant difference between sNRP-1 levels of CIN and cervical cancer groups (P > 0.05), while the sNRP-1 level of LECC was much lower than LACC group (P < 0.01, Figure 1(a))

Summary

Introduction

Cervical cancer is the fourth most common cancer in women worldwide, and it has the fourth highest mortality rate among cancers in women [1]. Most cases of cervical cancer are preventable by routine screening and by treatment of precancerous lesion. Cervical cancer is still one of the leading causes of morbidity and mortality for women in most Asian and African areas that lack adequate protocols. Increased angiogenesis at the site of the primary tumor is associated with poor prognosis and relapse of cervical cancer [2, 3]. During carcinogenesis of cervical cancer, most blood vessel networks are generated through angiogenesis. VEGF and its receptors VEGFR-1, VEGFR-2, and Neuropilin-1 (NRP-1) are targeted in therapeutic strategies for vascular disease and cancer. As a receptor for VEGF, NRP-1 protein is reported to be upregulated in several cancers [4, 5], whereas the soluble

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Conclusion