Abstract
This study aimed to investigate the expression of metastasis suppressor 1 (MTSS1) in cervical intraepithelial neoplasia (CIN) and malignant cervical tissues, and the role of MTSS1 in carcinogenesis. MTSS1 expression was detected by immunohistochemistry in 147 cervical tissue specimens collected from 30 healthy individuals, 30 patients with cervical CIN I, 30 patients with CIN II–III and 57 patients with cervical cancer. The association between MTSS1 expression and clinicopathological factors was also examined. MTSS1 was found to be positively expressed in 43.33% CIN I cervical tissues, 100% CIN II–III cervical tissues and 100% malignant cervical tissues, but was weakly or negatively expressed in benign cervical tissues. The positive expression rates of MTSS1 were significantly higher in CIN II–III and malignant cervical tissues than in CIN I or normal cervical tissues (P<0.05). When examining MTSS1 expression and clinicopathological factors, the strong positive MTSS1 expression rates in early-stage versus middle- and advanced-stage cervical cancer tissues were 39.13% and 82.35%, respectively. Furthermore, the positive expression rates of MTSS1 were significantly higher in cervical tissues at an advanced clinical stage than those at an early clinical stage (P<0.05). The results suggest that the dysregulation of MTSS1 may be involved in cervical carcinogenesis, and thus MTSS1 may be a novel diagnostic biomarker or therapeutic target in cervical cancer patients.
Highlights
Study has confirmed that persistent infection with high‐risk type human papilloma virus (HPV) may result in the gradual alteration of normal cervical epithelial tissue to cervical intraepithelial neoplasia (CIN), which may progress to cervical invasive carcinoma [1]
The epithelial cells in the CIN II‐III specimens exhibited moderate to strong Metastasis suppressor 1 (MTSS1) expression, and expression was detected over the entire epithelial layer (Figs. 1‐5)
Xie et al [10] demonstrated that MTSS1 expression levels in esophageal squamous cell carcinoma patients were significantly lower in high TNM stage tumors than in low TNM stage tumors, and MTSS1 expression levels were lower in patients with lymph node metastasis than in those without
Summary
Study has confirmed that persistent infection with high‐risk type human papilloma virus (HPV) may result in the gradual alteration of normal cervical epithelial tissue to cervical intraepithelial neoplasia (CIN), which may progress to cervical invasive carcinoma [1]. The underlying pathogenetic mechanism of cervical cancer, which may be a multigene, Key words: cervical malignancy, cervical intraepithelial neoplasia, metastasis suppressor 1 multifactor, multistep and multistage complex process, remains unclear. Previous studies have demonstrated that the coordinated regulation of cytoskeletal proteins is pivotal in motility, invasion and metastasis [2,3,4]. Metastasis suppressor 1 (MTSS1), termed missing in metastasis (MIM), is a newly identified actin binding protein that is mainly involved in cytoskeletal remodeling, signal transduction and transcriptional activation, and is closely associated with tumor growth and invasion [5]. The role of MTSS1 in cervical carcinogenesis was examined by investigating MTSS1 expression in pre‐cancerous cervical lesions and malignant cervical tissues, and by analyzing the association between MTSS1 expression and clinicopathological factors
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