Circulating levels of Elabela in pregnant women with missed abortion

Abstract

Objective This study aimed to detect Elabela concentrations in the serum of Missed abortion (MA) and compare them with the healthy pregnancies. Materials and methods This retrospective case-control study was performed in the second affiliated hospital, Xi’an Jiaotong University March 2019 to September 2019. A total of 108 healthy (35 early, 36 middle and 37 late) pregnant women and 25 (early gestational stage) MA patients were involved. Demographic and clinical characteristics were recorded. The concentration of plasma Elabela was examined using ELISA. Results The level of plasma Elabela was increased in early and middle stages and decreased in late stage of healthy pregnant women. Maternal serum Elabela levels were significantly lower in MA patients (4.59 ± 1.23 ng/mL) compared to healthy pregnant women (5.77 ± 1.21 ng/mL, p < 0.01). Conclusion Maternal circulating levels of Elabela were significantly lower in MA patients than in healthy pregnant women. We consider that Elabela might be a crucial biomarker of the pathophysiologic process in MA.