Correlation of thyroid and lipid profile in preeclampsia patient

Abstract

Background: Preeclampsia is a common medical complication during pregnancy, which affects approximately 8-10% in India and 6-8% of all pregnancies worldwide, most commonly after the 32nd week. It is associated with complications like premature birth, low birth weight and postpartum hemorrhage. Objectives: To estimate Lipid and Thyroid profile in Preeclampsia, Healthy pregnancy and Non pregnant women to assess the risk of lipid abnormalities and thyroid dysfunction in preeclampsia. To determine correlation of lipid and thyroid profile in preeclampsia patients and healthy pregnant women. Methods: This study comprised of three age matched groups consisting of 30 healthy non-pregnant women, 30 healthy pregnant women and 30 preeclampsia patients attending antenatal OPD and all pregnant women were at >28 weeks of gestation. Blood samples were collected 8-10 hours after fasting and the thyroid and lipid profiles were analyzed for comparison and correlation among them. Results: It was observed that T3, T4, TSH, total cholesterol, triglyceride and VLDL increased significantly in preeclampsia patients when compared to both healthy pregnant and non pregnant women. Whereas T3, T4, total cholesterol, triglyceride and VLDL were increased significantly in healthy pregnant women when compared to healthy non pregnant women. Significant positive correlation was seen between TSH and Triglycerides (p < 0.05) also seen between T3 and total cholesterol (p < 0.05), T3 and LDL (ρ < 0.05) in preeclampsia patients. Conclusion: Correlation of Lipid and Thyroid profile. Screening for dyslipidemia and thyroid dysfunction in Preeclampsia is essential to prevent medical complications during Pregnancy.