Abstract
Circulating immune complexes(IC) were measured in anaphylactoid purpura(AP) with or without renal involvement of children. IC were measured by 4% polyethlene glycol precipitated method. IC levels of IgG, IgA and IgE in AP were higher than in control and moreover these IC levels in cases with renal involvement were higher than in cases without renal involvement except IC of IgM. The frequency of complicated purpura nephritis in 98 cases of AP (1976-1979) treated with prednisolone(1-2mg/kg/day) was compared with that in 104 cases of AP(1963-1971) treated with small doses of steroid or without steroids. According to the data, the frequency in both groups showed the significant difference; 18.4% in the former group and 35.6% in the latter group. It may suggest that sufficient steroid therapy during the initial stage in AP shows prophylactic effect on complicated nephritis.
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