Abstract
We investigated the behavior of circulating endothelial cells (CEC) in patients with hepatocellular carcinoma (HCC) receiving sorafenib, and whether CEC levels were associated with time to progression (TTP). CECs in advanced HCC patients receiving sorafenib were counted at baseline and every 4 weeks. Twenty four HCC patients were enrolled in the study. Median TTP was 3.2 months (1-6). Median baseline CEC levels were 67 cells/ml, with an increase of 169.8% after 4weeks of treatment. Any time CEC levels in patients with a TTP lower than 4months were higher, but not statistically significant, compared with those in patients with TTP more than 4months. Treatment with sorafenib changed CEC levels in HCC patients.
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