Abstract
Background Primary angiitis of the central nervous system in children (cPACNS) is an inflammatory vasculitis that solely affects the CNS vessels in the absence of a systemic inflammatory process. Circulating endothelial cells (CECs) are increasingly described as biomarkers for tracking vascular injury [1]. Additionally, bone marrow-derived endothelial progenitor cells (EPCs) are thought to play a pivotal role in the regeneration of damaged endothelium. We describe the relationship of CECs and EPCs to clinical and/or radiological disease progression in cPACNS.
Highlights
Primary angiitis of the central nervous system in children is an inflammatory vasculitis that solely affects the CNS vessels in the absence of a systemic inflammatory process
We describe the relationship of Circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) to clinical and/or radiological disease progression in cPACNS
Ease compared to child controls (p = 0.005) and patients with non progressive disease (p = 0.03)
Summary
Primary angiitis of the central nervous system in children (cPACNS) is an inflammatory vasculitis that solely affects the CNS vessels in the absence of a systemic inflammatory process. Circulating endothelial cells (CECs) are increasingly described as biomarkers for tracking vascular injury [1]. Bone marrow-derived endothelial progenitor cells (EPCs) are thought to play a pivotal role in the regeneration of damaged endothelium. We describe the relationship of CECs and EPCs to clinical and/or radiological disease progression in cPACNS. Ease compared to child controls (p = 0.005) and patients with non progressive disease (p = 0.03). There was a similar but non significant trend for EPCs expressing CD34/ CD133/VEGFR2
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