Abstract
The aim of this study was to investigate the link between circulating adiponectin levels and peak oxygen uptake and/or physical activity in Japanese. A total of 528 subjects (188 men and 340 women) were enrolled in this cross-sectional study. Circulating adiponectin levels, physical activity measured by tri-axial accelerometers, peak oxygen uptake and metabolic risk parameters were evaluated. We also assessed anthropometric factors, blood pressure, blood examinations and energy intake. Circulating adiponectin levels were 6.7 ± 3.0 μg/mL in men and 11.0 ± 4.9 μg/mL in women. Circulating adiponectin levels were positively correlated with physical fitness after adjusting for age, physical activity evaluated by Σ [metabolic equivalents × h per week (METs h/w)], cigarette smoking habit and energy intake in both sexes. However, these associations were attenuated further after adjusting for body mass index including other confounding factors, especially in men. However, circulating adiponectin levels were not associated with physical activity in either sex. Circulating adiponectin levels were associated with peak oxygen uptake rather than physical activity.
Highlights
MethodsAfter the subjects fasted and rested overnight for 10–12 h, blood samples were collected to determine circulating levels of adiponectin, high-density lipoprotein (HDL) cholesterol, triglycerides (L Type Wako Triglyceride H, Wako Chemical, Osaka, Japan) and blood glucose
Circulating adiponectin levels were positively correlated with physical fitness after adjusting for age, physical activity evaluated by R [metabolic equivalents 9 h per week (METs h/w)], cigarette smoking habit and energy intake in both sexes
Circulating adiponectin levels were associated with peak oxygen uptake rather than physical activity
Summary
After the subjects fasted and rested overnight for 10–12 h, blood samples were collected to determine circulating levels of adiponectin, high-density lipoprotein (HDL) cholesterol, triglycerides (L Type Wako Triglyceride H, Wako Chemical, Osaka, Japan) and blood glucose. Circulating adiponectin levels were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit (Otsuka Pharmaceuticals; Tokyo, Japan). We used data for 528 subjects (188 men and 340 women) among 1,118 subjects who met the following criteria: (1) wanted to volunteer in the Nutrition and Exercise Intervention Study (NEXIS) at the National Institute of Health and Nutrition, Tokyo, Japan and Okayama Southern Institute of Health, Okayama Health Foundation, Okayama, Japan; (2) had received anthropometric, physical activity, peak oxygen uptake, blood pressure (BP) measurements and blood examinations including circulating adiponectin levels; (3) received no medications for conditions such as diabetes, hypertension and dyslipidemia; and (4) provided written informed consent (Table 1)
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