Abstract
Yang et al. established a novel type of circular mRNA called cmRNA. cmRNA contains an echovirus 29-derived internal ribosomal entry point element to promote ribosome binding and a newly designed spacer to enhance translation. Their findings suggest that this type of circular mRNA can mediate strong and persistent expression of various types of proteins. Furthermore, in addition to delivery via lipid nanoparticle (LNP), cmRNAs were discovered suitable for direct intratumoral administration. By giving mice cmRNAs encoding mixed cytokines directly intratumorally, they achieved successful modulation of intratumoral and systemic antitumor immune responses and enhanced anti-programmed cell death protein 1 (PD-1) antibody-induced tumor suppression.
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