Abstract

circRNAs, as a kind of non-coding RNA, are characterized by rich content, high stability, and tissue specificity, and have become a research focus in recent years. A large number of studies have found that circRNA and miRNA have the strongest binding capacity among competing endogenous RNAs, playing a role as a miRNA molecular sponge in cellular gene expression and playing an important role in many diseases. At present, studies have shown that circRNAs are closely related to cerebrovascular diseases and play a crucial role in vascular endothelial cells, metabolism of low-density lipoprotein, smooth muscle cells, inflammatory oxidative stress, ischemia-reperfusion, and other regulatory mechanisms. In order to systematically understand circRNA and its function, in order to understand the research progress of circRNA in regulating the molecular mechanism of cerebrovascular diseases, and in order to find potential markers and drug molecules in the field of cerebrovascular disease occurrence, development, diagnosis, and treatment targets, we reviewed the research progress of circRNA in the development of cerebrovascular disease.

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