Abstract
Summary A depressed fibrinolytic activity and an increased platelet stickiness during the morning hours has been suggested to be related to the frequent onset of myocardial infarction at that time in caucasians. We have studied the fibrinolytic system in blood samples collected every 4h during 24h from Eskimos (n=10), reported to have low prevalence of myocardial infarction. We found no differences in plasminogen activator inhibitor (PAI)-1, determined in blood stabilised with citrate or in blood stabilised with citrate containing antiplatelet agents. Absence of platelet contribution to PAI-1 fluctuations was confirmed by platelet factor 4 (PF4) measurements. Tissue-type plasminogen activator (t-PA) activity (p
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