Abstract
The aim of the present study is to demonstrate a sustained drug delivery in simulated gastro-intestinal system to target enteropathogenic bacteria. Herein, we report a straightforward method to synthesize model drug ciprofloxacin loaded genipin cross-linked chitosan/heparin nanoparticles (CIPRO-GP-CS/Hep NPs) by ionic gelation. The physiochemical characteristics were analyzed using FTIR, DLS, and FESEM. The synthesized particles had a spherical shape with z-average of 250nm and zeta potential +32mV. The antibacterial activity of the CIPRO-GP-CS/Hep NPs was evaluated against Escherichia coli MTCC 443, which showed that it can be used as an antibacterial agent. In vitro drug release study at simulated gastro-intestinal pH conditions demonstrated that the CIPRO-GP-CS/Hep NPs exhibited a sustained release property.
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