Abstract
Infertility affects more than 40–50% of couples, with men accounting for 20–30% of the problem. Spermatogenesis fails due to poor sperm quality. Although external factors of smoking, alcohol, heat, and metal exposure cause testicular damage, causes infertility than genetic factors. However, after infection with COVID-19, the SARS-CoV-2 virus enters the blood-testis barrier via ACE2 receptors influenced hypertension and disrupts spermatogenesis. Meanwhile, preserving sperm cells during treatment or medication and the associated freeze/thaw is difficult. As a result, the current pilot study focuses on maintaining hypertension-induced infertile subjects' sperm cells by cinnamon extender and its ameliorative effect on sperm viability (SARS-CoV-2 recovered patients after six months were identified and selected). The semen was collected with proper institutional permission from the 20–45 age group with infertility (recently recovered from COVID-19) and processed for major conventional semen parameters as per WHO, 2020. The informed consent form was obtained and kept confidential. Cinnamon NPs were synthesized, characterized, and processed for sperm preservatives at specific dosages (15, 25, and 50 ppm) and time intervals, followed by biochemical and viability analysis. Because the last two years of COVID-19 have had an impact on their lifestyle, the semen parameters (count, morphology, and motility) and biochemical parameters (Ca, Na, K, Se, Mg, and total seminal proteins) confirm that they are infertile due to high blood pressure. Cinnamon-ZnO NPs treated sperm cells, and their viability indicates that improved viability of infertile sperm cells was comparable to fertile and that further damage from infertility was avoided noticeably. Cinnamon is high in zinc and has antioxidant properties; it can be used as a cryopreservative.
Published Version
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