Abstract
Cigarette smoking remains a significant health threat for smokers and nonsmokers alike. Secondhand smoke (SHS) is intrinsically more toxic than directly inhaled smoke. Recently, a new threat has been discovered – Thirdhand smoke (THS) – the accumulation of SHS on surfaces that ages with time, becoming progressively more toxic. THS is a potential health threat to children, spouses of smokers and workers in environments where smoking is or has been allowed. The goal of this study is to investigate the effects of THS on liver, lung, skin healing, and behavior, using an animal model exposed to THS under conditions that mimic exposure of humans. THS-exposed mice show alterations in multiple organ systems and excrete levels of NNAL (a tobacco-specific carcinogen biomarker) similar to those found in children exposed to SHS (and consequently to THS). In liver, THS leads to increased lipid levels and non-alcoholic fatty liver disease, a precursor to cirrhosis and cancer and a potential contributor to cardiovascular disease. In lung, THS stimulates excess collagen production and high levels of inflammatory cytokines, suggesting propensity for fibrosis with implications for inflammation-induced diseases such as chronic obstructive pulmonary disease and asthma. In wounded skin, healing in THS-exposed mice has many characteristics of the poor healing of surgical incisions observed in human smokers. Lastly, behavioral tests show that THS-exposed mice become hyperactive. The latter data, combined with emerging associated behavioral problems in children exposed to SHS/THS, suggest that, with prolonged exposure, they may be at significant risk for developing more severe neurological disorders. These results provide a basis for studies on the toxic effects of THS in humans and inform potential regulatory policies to prevent involuntary exposure to THS.
Highlights
Despite efforts by governments and health organizations worldwide, cigarette smoking remains a serious health threat for smokers and nonsmokers alike [1,2,3,4]
We have developed a mouse model for thirdhand smoke (THS) exposure that approximates that of children and others in environments contaminated by THS (Materials and Methods)
Materials commonly present in the homes and cars of smokers are exposed for specific periods of time to secondhand smoke (SHS) from a smoking machine, 6 hrs/day, 5 days/wk for 24–26 wks, at a total particulate matter (TPM) of 30+/25 mg/m3, a value that falls within the range detected by the Environmental Protection Agency (EPA) in the homes of smokers (15–35 mg/m3) [22,23]
Summary
Despite efforts by governments and health organizations worldwide, cigarette smoking remains a serious health threat for smokers and nonsmokers alike [1,2,3,4]. Tobacco smoking causes significant human disease and economic burden worldwide, afflicting approximately 1.5 billion smokers while additional billions are at underappreciated health risk from exposure to cigarette smoke, with estimated annual costs of hundreds of billions of dollars. It has become clear that health threats are serious for children who constitute a vulnerable population that cannot voluntarily avoid secondhand smoke (SHS). Its expansion to many countries, was achieved only because of clear scientific evidence that SHS is dangerous to non-smokers. More than 20 years later, evidence is emerging that THS exposure potentially poses similar health risks, especially for children. Public convictions and support of THS exposure-control policies depend on biological evidence of THS toxicity
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
