Abstract
Dissociated newborn rat superior cervical ganglion neurons in culture without exogenous nerve growth factor survive and extend processes on a monolayer of rat heart ventricular cells. An increase in the contraction rate of the heart cells was observed in 83% of the co-cultures treated with 5 × 10 −6 M. tyramine. No increase was seen in heart cell cultures without neurons. These results are consisted with the assumed mode of action of tyramin— the release of catecholamines from nerve terminals - and suggest that functional interaction can occur in culture between sympathetic neurons and heart vettricular cells
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