Abstract
The Sri Lankan Journal of Infectious Diseases (SLJID) is an open access, peer-reviewed, biannual journal published by the Sri Lankan Society for Microbiology (SSM). The Journal considers articles from all professional disciplines involved in the field of infectious diseases. The Journal has been in publication since 2011, is included in the DOAJ since 2018 and is a member of COPE since 2021. The SLJID practices a double-blind peer review policy. From 2022, the SLJID publishes accepted manuscripts online immediately after copy-editing, enabling rapid dissemination of scientific knowledge. The published articles are subsequently compiled into two issues in April and October. The SLJID does not charge any article processing or publication fee.
Highlights
The primary function of normal intact skin is to prevent invasion by potential pathogens that live on the skin and pathogens from other exogenous sources from entering the body
Our understanding of wound-healing mechanisms has tremendously improved over the past decade with the identification of the role of different cell types and description of different chemokines involved in wound healing
Fibroblasts in chronic wounds have impaired responsiveness to growth hormone, which may be due to an increased number of senescent cells.[13,14]
Summary
The primary function of normal intact skin is to prevent invasion by potential pathogens that live on the skin and pathogens from other exogenous sources from entering the body. Namely ‘the wound’ provides a suitable environment for microbial colonization and propagation that could harm the body. The abundance and diversity of microorganisms in any wound will be influenced by factors such as wound type, depth, location and quality, level of tissue perfusion and the antimicrobial efficacy of the host immune response. The microflora associated with clean surgical wounds would be expected to be minimal and limited to skin commensals. The presence of foreign material and devitalized tissue in a traumatic wound facilitates microbial proliferation including regional flora as well as flora from other sources. Antibiotic therapy and surgical debridement would minimize such complications.[1]
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