Chronic treatments with 5-HT 1A agonists attenuate posthypoxic myoclonus in rats

Abstract

Following 10 min cardiac arrest and resuscitation, male Sprague-Dawley rats developed posthypoxic myoclonus. This phenomenon peaked at 14 days and disappeared by 60 days after cardiac arrest. From previous results, the 5-hydroxytryptamine (5-HT) system was implicated in the pathogenesis of the disease. In the present study, we investigated the involvement of 5-HT 1A receptors in posthypoxic myoclonus in rats. Single injections of 5-HT 1A agonists, buspirone (5 and 10 mg/kg body wt.) or 8-OH-DPAT (1, 2, and 4 mg/kg), had no effect on either the intensity or time course of the disease. In contrast, multiple injections (twice a day for 7 or more days) of buspirone (10 mg/kg) or 8-OH-DPAT (4 mg/kg) significantly attenuated the myoclonus scores of animals ( p < 0.05). The results indicate that chronic stimulation of 5-HT 1A receptors in the brain may accelerate endogenous compensatory mechanisms and shorten the time course of the disease.