Chronic Transplant Glomerulopathy

Abstract

The AJKD Atlas of Renal Pathology presents a compilation of figures on a specific pathologic entity. You may download the figures to create your own personal, non-commercial library of images or to create slides for teaching purposes. The AJKD Atlas of Renal Pathology presents a compilation of figures on a specific pathologic entity. You may download the figures to create your own personal, non-commercial library of images or to create slides for teaching purposes. Fig 2Chronic transplant glomerulopathy is manifest by light microscopy by extensive glomerular basement membrane splitting. Typically, there is less endocapillary proliferation than in an immune complex mediated membranoproliferative glomerulonephritis, which can easily be excluded by lack of immune complexes by immunofluorescence and electron microscopy. (Jones' Silver Stain, original magnification ×400).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 3In chronic transplant glomerulopathy, there may be segmental sclerosis and even hyalinosis in addition to glomerular basement membrane splitting. (Jones' Silver Stain, original magnification ×1,000).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 4Glomerular basement membrane splitting with so-called “mesangial” interposition is illustrated in this case of chronic transplant glomerulopathy. Some of the interposed cells are actually macrophages by immunophenotyping. (Jones' Silver Stain, original magnification ×1,000).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 5Chronic transplant glomerulopathy is thought to be due to chronic endothelial injury with resulting increased lucency of the lamina rara interna and occasional interposition, without any immune complexes, as shown in this electron micrograph. (Transmission electron microscopy, original magnification ×3,000).View Large Image Figure ViewerDownload Hi-res image Download (PPT)