Abstract
Chronic prurigo is avery debilitating skin condition characterized by the development of multiple pruriginous nodules, papules or plaques due to aprolonged scratching behavior as aresult of chronic itch. Patients often experience anxiety, depression or sleep impairment leading to asubstantial decrease in quality of life. Due to the complex pathophysiology and diversity in clinical presentation, managing chronic prurigo remains achallenge. Disease-specific guidelines provide appropriate diagnostic measures and recommend astep-wise therapeutic approach. With the increase of pharmaceutical interest in chronic prurigo, several innovative therapies including monoclonal antibodies and small molecules are currently being investigated for chronic prurigo. This continuing medical education (CME) article provides an overview on various aspects of chronic prurigo, especially on epidemiology, pathophysiology, clinical presentation, diagnostic and therapeutic approach, and innovate therapeutic options.
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