Chronic pancreatitis in comorbidity with gastroesophageal reflux disease (features of the course of gastroesophageal reflux disease)

Abstract

In this article, the authors emphasize the relevance of studying the features of the course of gastroesophageal reflux disease (GERD) both in children and adults, and in old age (including chronic pancreatitis). Attention is drawn to the different important mechanisms of GERD development in children and adults. As it is impossible to collect anamnesis in children before they start speaking, it is necessary to ask the parents about the so-called “red flags” (frequent fountain-like vomiting, the child is badly gaining weight, repeated pneumonia, diarrhea, refusal to drink or eat). One of the important features is a child’s crying during 1–2 hours.
 It is difficult to make a differential diagnosis in adults between GERD phenotypes, especially in comorbidity with chronic pancreatitis, which makes appropriate adjustments to the clinical picture (which the authors focus on). Differential diagnosis of non-erosive GERD, such GERD phenotypes as reflux esophageal hypersensitivity, functional heartburn, low and high grade reflux esophagitis, Barrett’s esophagus, regurgitation-dominant GERD, extraesophageal phenotype and reflux chest pain syndrome is carried out.
 The authors agree with those provisions that indicate that GERD is a family of different syndromes that differ in the mechanisms of development, clinical picture and make up certain phenotypes of the disease, which require a differentiated approach to treatment tactics and strategies, secondary prevention (including chronic pancreatitis).