Abstract
Cytokines are considered as “microendocrine system” due to the fact that they have a triple mechanism of action. First, they affect the cell-producer (autocrine effect); secondly, they influence neighboring (adjacent) cells (paracrine effect); thirdly, they affect the distant cells of organs and tissues (endocrine effect). Most cytokines have a wide range of biological activity, which is associated with their synthesis and secretion of various types of cells.
 Aim of study was to determine the role and prognostic values of tumor necrosis factor (TNF) α, interleukin (IL) 1β and IL-18 in young patients with autoimmune thyroiditis (AIT) and gastroesophageal reflux disease (GERD).
 Materials and methods. Study involved 83 patients (students) with GERD and AIT. The average age for the group was 22.1±2.11 years. The comparison group was represented by 30 patients of similar age with isolated GERD. The enzyme immunoassay was used to study the content of TNF-α, IL-1β and IL-18.
 Results. Upon evaluating the complaints of patients, it was found that the main manifestation of GERD was heartburn of varying severity, duration and frequency of occurrence. It has been shown that the course of GERD occurs against the background of the development of a systemic inflammatory reaction (increased synthesis of proinflammatory cytokines IL-1β and TNF-α), and also depends on the form of esophagitis: more pronounced in the erosive variant of the mucous membrane of the esophagus. At the same time, there was an increase in the synthesis of IL-18, which, with isolated GERD, is associated with a general inflammatory reaction, and with the addition of AIT, the inclusion of immune mechanisms. Relationship between the level of TNF-α in peripheral blood and the content of thyroid-stimulating hormone was studied. However, unlike the results of other scientists, the authors have not identified such a relationship.
Highlights
На теперішній час доведено існування понад сот ні цитокінів, які беруть участь у багатьох процесах в організмі [12]
Підвищення вмісту прозапальних цитокінів та за лежність їх вмісту від морфологічних змін у слизо вій оболонці стравоходу у хворих молодого віку на гастроезофагеальну рефлюксну хворобу (ГЕРХ) та автоімунним тиреоідитом (АІТ) є результатом розвитку загальної го строфазової відповіді та її місцевого посилення при формуванні ерозій
Aim of study was to determine the role and prognostic values of tumor necrosis factor (TNF) α, interleukin (IL) 1β and IL-18 in young patients with autoimmune thyroiditis (AIT) and gastroesophageal reflux disease (GERD)
Summary
На теперішній час доведено існування понад сот ні цитокінів, які беруть участь у багатьох процесах в організмі [12]. В такому разі є доцільним визначення ролі ФНП-α, ІЛ-1β та ІЛ-18 у хворих на гастроезофагеальну рефлюксну хворобу (ГЕРХ), що перебігає у молодих пацієнтів з автоімунним тиреоідитом (АІТ). Метою роботи було визначення ролі та прогнос тичного значення ФНП-α, ІЛ-1β та ІЛ-18 у хворих молодого віку з поєднаним перебігом АІТ та ГЕРХ.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
