Chronic Obstructive Pulmonary Disease Exacerbations

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PART I INTRODUCTION Definitions and severity of COPD exacerbations: Stephen Rennard and Nancy Kline Leidy Epidemiology of COPD exacerbations: David Mannino Differential diagnosis of COPD exacerbations: Peter Calverley PART II MECHANISMS AND PATHOPHYSIOLOGY Symptom changes at exacerbations: Terry Seemungal Airway pathology at exacerbations: Marina Saetta Airway and systemic inflammatory markers at exacerbation: John Hurst Physiological changes at exacerbations: Dennis O'Donnell and Chris Parker Systemic consequences of COPD exacerbations: Emiel Wouters Mechanisms of respiratory failure at exacerbation: Roberto Rodriguez Roisin Role of respiratory viral infection at exacerbation: Wisia Wedzicha and Jennie Quint Do airway bacteria cause COPD exacerbations: Sanjay Sethi Interactions of airway pathogens and inflammatory processes: Alberto Papi Role of co-morbidity at COPD exacerbations: Bill MacNee, John Maclay and David McAllister Environmental causes of exacerbations: David Hui and Fanny Ko Mechanisms and pathophysiological changes in alpha-1 AT deficiency exacerbations: Rob Stockley Experimental models of COPD exacerbations: Jeff Curtis Comparison of asthma and COPD exacerbations: Sebastian Johnston PART III IMPACT OF EXACERBATIONS Exacerbations and health status: Paul Jones Risk factors for hospital admission: Judith Garcia Aymerich Effect of exacerbations on disease progression and mortality: Gavin Donaldson Health economic consequences of COPD exacerbations: Marc Miravitlles PART IV MANAGEMENT OF THE ACUTE EXACERBATION Use of bronchodilators and mucolytics at COPD exacerbations: Marc Decramer Corticosteroids in the management of acute exacerbations: Denis Niewoehner Antibiotic therapy at COPD exacerbations: Rob Wilson Non invasive ventilatory support: Mark Elliott and Stanley Miller Invasive ventilation and weaning at COPD exacerbation: Antonio Anzueto Oxygen therapy at exacerbations: Tony Davison and Luke Wilson End of life issues and COPD exacerbations: Anita Simonds Novel models of care for COPD exacerbations: Martyn Partridge Physiotherapy airway clearance at exacerbation: Christine Mikelsons and Rachel Garrod COPD exacerbation and pulmonary rehabilitation: Mike Polkey and William Mann PART V PREVENTION OF COPD EXACERBATION Pharmacological prevention of COPD exacerbations: Leo Fabbri Early intervention and self-management in exacerbation prevention: Jean Bourbeau Immunological interventions: Phillip Poole Home mechanical ventilation and oxygen therapy: Gerry Criner and Nat Marchetti PART VI ISSUES FOR STUDIES OF COPD EXACERBATIONS Design of trials for COPD exacerbations: Fernando Martinez Statistical considerations for COPD exacerbation trials: Shawn Aaron Future development in COPD exacerbations: Peter Barnes