Chronic liver disease during a pandemic: preventive support for the combined phytopreparation Fumarta

Abstract

The spread of SARS‑CoV‑2 virus among humanity has identified a number of new challenges in the field of medical science. In this regard, it is very important to understand the possible involvement of the liver in the infectious process, as well as the effect of this virus on liver function in its chronic pathology. The article provides an overview of available sources of information regarding views on direct viral liver damage COVID‑19, as well as the features of the course and prognosis of this infection in patients with chronic liver disease and cirrhosis. It was emphasized that chronic liver diseases are considered as a high risk factor for COVID‑19 infection, and are also predicted to be at an increased risk for the severe course of this infection with the development of complications.Substantial support to patients with chronic liver diseases during the COVID‑19 pandemic can be provided by the Fumarta combination drug (Farmak), which includes fumarin alkaloid from the extract of dry herb of the fumaria officinalis and silymarin from the extract of dried fruit of milk thistle. This composition of the drug Fumarta allows normalizing the digestive disorders, which constantly accompany chronic liver disease. In the article, digestive disorders are considered from the point of view of biliary insufficiency, which occurs in virtually every chronic liver disease. Normalization of the formation of bile, its composition with the restoration of rheological properties, improves not only general well‑being of a patient, but also positively affects the restoration of the functional capabilities of the liver. The data on the study of each of the active components of the Fumarta drug are presented, which indicates the advisability of its use in this group of diseases.The healing properties of the Fumarta drug are stipulated by the optimal combination of the hepatoprotective effects of silymarin with the normalization of bile secretion and biliary motility by fumarin. The combination of hepatoprotective and choleretic activity complement and enhance the action of each other, which helps to optimize the functioning of the entire digestive system. Patients with liver disease in the context of the COVID‑19 pandemic are recommended to take Fumarta drug, the components of which have a versatile positive effect in chronic liver diseases as preventive support. Approaches to pharmacotherapy of chronic liver diseases among the convalescents of COVID‑19 are also being considered. In this regard, Fumarta may act as one of the optimal drugs for choosing a rehabilitation course for these patients.